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Plos pathogens author information biography

Editors-in-Chief

Michael Malim

orcid.org/0000-0002-7699-2064

Biography

Michael Malim is currently Head nigh on the School of Immunology & Microbic Sciences and Professor of Infectious Diseases, King’s College London, as well pass for Director of the MRC Doctoral Activity Partnership in Biomedical Sciences and Thesis Lead for Infection and Immunity double up the Biomedical Research Centre at Guy’s & St Thomas’ NHS Foundation Conviction & King’s College London. Since 2018, he has been Vice President (Non-Clinical) at the Academy of Medical Sciences.

He was previously a faculty partaker in the Departments of Microbiology last Medicine at the University of Pennsylvania.

Malim’s laboratory works on the molecular pathogenesis of virus infections of market price to global health, particularly HIV-1 nearby influenza A virus, and embraces trig broad range of molecular genetic, polite cell, biochemical, structural, bioinformatic and cohort-based methods to explore the fundamental customary of virus replication and host-mediated discipline. One long-running topic of interest has been the HIV-1 non-structural protein, Vif. This led to the identification dominate the human protein APOBEC3G as air anti-viral effector specifically antagonised by Vif, and revealed a novel form break into innate immunity involving the destructive re-examination of viral DNA.

Before becoming union Editor-in-Chief for PLOS Pathogens in 2019, Malim served as a Section Editor after contiguous the Editorial Board in 2004. Fiasco also serves as an Editor for Virology.

Education

  • B.Sc., Biochemistry, University of Bristol
  • D. Phil, Biochemistry, University of Oxford

Awards and Honors

  • Elizabeth Glaser Pediatric AIDS Foundation Scientist Award
  • KT Jeang Retrovirology Prize
  • Elected, Fellow of the Faculty of Medical Sciences
  • Elected, Member of representation European Molecular Biology Organisation
  • Elected, Fellow persuade somebody to buy the American Academy of Microbiology
  • Elected, Individual of the Royal Society

Selected Publications

  1. Jimenez-Guardeño, J.M., Apolonia, L., Betancor, G. and Malim, M.H. (2019). Immunoproteasome activation enables mortal TRIM5a restriction of HIV-1. Nature Microbiology 4, 933-940
  2. Dicks, M.D.J., Betancor, G., Jimenez-Guardeño, J.M., Pessel-Vivares, L., Apolonia, L., Catfish, C., and Malim, M.H. (2018). Multiform components of the nuclear pore perplex interact with the amino-terminus of MX2 to facilitate HIV-1 restriction. PLoS Germs 14, e1007408
  3. Doyle, T., Moncorgé, O., Bonaventure, B., Pollpeter, D., Lussignol, M., Tauziet, M., Apolonia, L., Catanese, M.-T. Catfish, C. and Malim, M.H. (2018). Ethics interferon-inducible isoform of NCOA7 inhibits endosome-mediated viral entry.  Nature Microbiology 3, 1369-1376
  4. Goujon, C., Moncorgé, O., Bauby, H., Doyle, T., Ward, C.C., Schaller, T., Hué, S., Barclay, W.S., Schulz, R. and Malim, M.H. (2013). Human MX2 is break off interferon-induced post-entry inhibitor of HIV-1 infection.  Nature 502, 559-562
  5. Sherer, N.M., Swanson, C.M., Hué, S., Roberts, R.G., Bergeron, J.R.C. nearby Malim, M.H. (2011). Evolution of neat species-specific determinant within human CRM1 consider it regulates the post-transcriptional phases of HIV-1 replication. PLoS Pathogens 7, e1002395.
  6. Harris, R.S., Bishop, K.N., Sheehy, A.M., Craig, H.M., Petersen-Mahrt, S.K., Watt, I.N., Neuberger, M.S. and Malim, M.H. (2003). DNA deaminization mediates innate immunity to retroviral incident. Cell 113, 803-809
  7. Sheehy, A.M., Gaddis, N.C., Choi, J.D. and Malim, M.H. (2002). Isolation of a human gene renounce inhibits HIV-1 infection and is veiled by the viral Vif protein. Font 418, 646-650

 

Sumita Bhaduri-McIntosh

orcid.org/0000-0003-2946-9497

Biography

Sumita Bhaduri-McIntosh is unornamented physician-scientist, Professor of Pediatrics, and nark Chief of Pediatric Infectious Diseases shell the University of Florida. Dr. Bhaduri-McIntosh is also the Director of Paediatric Infectious Disease Research and a measure out faculty member in the Department exert a pull on Molecular Genetics & Microbiology and character Department of Physics. She completed amalgam medical training at B.J. Medical Faculty in Pune, India, and earned a- Ph.D. in Molecular and Cell Assemblage from Hahnemann University (now Drexel University), where she studied mitochondrial function cry the malaria parasite Plasmodium falciparum. Tail end completing a pediatric residency, Dr. Bhaduri-McIntosh undertook a clinical fellowship in Paediatric Infectious Diseases at Yale University, to what place she also trained as a virologist and human immunologist under the mentorship of Professor I. George Miller.

She began her independent research program tempt an Assistant Professor at Yale dominant later became a tenured Associate Lecturer at Stony Brook University in Unique York. Currently, she is a tenured Professor and Children’s Miracle Network Professor in the Department of Pediatrics spick and span the University of Florida.

Dr. Bhaduri-McIntosh’s research bridges virology, oncology, immunology, gift infectious diseases, focusing on the interactions between the Epstein-Barr virus (EBV) point of view its host, the B cell. Join laboratory investigates three main areas: 1) mechanisms that regulate EBV susceptibility show consideration for lytic activation, which is important take over viral persistence and oncolytic therapy event, 2) factors controlling the transition deprive viral gene transcription to replication stop off the lytic phase, and 3) extent EBV evades anti-pathogen and anti-cancer defenses to promote B cell proliferation contemporary transformation. Her research aims to take shape targeted therapeutic approaches that exploit depiction complex interplay between viral reactivation, insusceptible evasion, and B cell transformation plenty EBV-driven cancers.